TERREIN

Synonym(s):(+)Terrein;Terrain

CAS NO.：582-46-7
Empirical Formula: C8H10O3
Molecular Weight: 154.16
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-17 09:49:50

What is TERREIN?

The Uses of TERREIN

Terrein is a polar, substituted dihydrocyclopentenone first reported by Raistrick and colleagues in the 1930s and subsequently found in a number of Aspergillus and Penicillium species. For many years the biological profile and mode of action of terrein was unstudied; however, recent research showed that terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation, followed by MITF down-regulation. Terrein also reduces human keratinocyte proliferation by inhibiting ERK and by decreasing the expression of cyclin B1 and Cdc2 complex.

The Uses of TERREIN

Terrein (cas# 582-46-7) is a compound useful in organic synthesis.

Definition

ChEBI: Terrein is a polyol.

Properties of TERREIN

Melting point:	125-127℃
Boiling point:	327.2±42.0 °C(Predicted)
Density	1.449±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	H2O: soluble1-1.10 mg/mL, clear, colorless
pka	11.77±0.60(Predicted)
form	A solid

Safety information for TERREIN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.