TAPI-0

CAS NO.：163958-73-4
Empirical Formula: C24H32N4O5
Molecular Weight: 456.53
Update Date: 2026-01-13 11:18:13

What is TAPI-0?

The Uses of TAPI-0

TAPI 0 is a metalloprotease inhibitor, which inhibits the obligate intracellular human pathogen Chalmydia trachomitis.

Biochem/physiol Actions

TAPI-0 is a metalloproteinase inhibitor with selectivity for TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). TAPI-0 also inhibits of collagenase and gelatinase. Although not specific for TACE, TAPI-0 is extensively used to block TACE-mediated TNF-α shedding.

Storage

Store at -20°C

Properties of TAPI-0

Density	1.227±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO
form	powder
pka	9.17±0.20(Predicted)
color	white to off-white

Safety information for TAPI-0

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral

Computed Descriptors for TAPI-0

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