TA-01

CAS NO.：1784751-18-3
Empirical Formula: C20H12F3N3
Molecular Weight: 351.32
MDL number: MFCD30182287
Update Date: 2026-04-22 18:57:36

What is TA-01?

Description

TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation. It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5^eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.

The Uses of TA-01

TA 01 induces cardiomyocyte differentiation of pluripotent stem cells.

Properties of TA-01

Boiling point:	511.1±50.0 °C(Predicted)
Density	1.337±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml; DMSO: 3 mg/ml
form	A crystalline solid
pka	9.26±0.24(Predicted)
color	White to off-white

Safety information for TA-01

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for TA-01

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