t-Boc-N-amido-PEG2-NHS ester

CAS NO.：2183440-73-3
Empirical Formula: C16H26N2O8
Molecular Weight: 374.39
MDL number: MFCD31381627
Update Date: 2026-05-28 05:20:16

What is t-Boc-N-amido-PEG2-NHS ester?

Description

t-Boc-N-amido-PEG2-NHS ester is a PEG linker containing an NHS ester and a t-Boc protected amine group. The hydrophilic PEG spacer increases the solubility of compounds in aqueous media. The t-Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Properties of t-Boc-N-amido-PEG2-NHS ester

Density	1.24±0.1 g/cm3(Predicted)
solubility	Soluble in DCM
pka	12.22±0.46(Predicted)
form	Solid
color	White to off-white
InChI	InChI=1S/C16H26N2O8/c1-16(2,3)25-15(22)17-7-9-24-11-10-23-8-6-14(21)26-18-12(19)4-5-13(18)20/h4-11H2,1-3H3,(H,17,22)

Safety information for t-Boc-N-amido-PEG2-NHS ester

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.