Sulfacetamide sodium

Chemical properties

White or yellowish-white, crystalline powder.

The Uses of Sulfacetamide sodium

Sulfacetamide sodium salt hydrate is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. It adapts to cure trachoma, conjunctivitis, keratitis.

The Uses of Sulfacetamide sodium

Antibacterial;Inhibitor of folic acid synthesis

Definition

ChEBI: Sulfacetamide sodium is an organic sodium salt that is the monohydrate form of sulfacetamide sodium. It has a role as an antimicrobial agent, an antiinfective agent and an EC 2.5.1.15 (dihydropteroate synthase) inhibitor. It is an organic sodium salt and a hydrate. It contains a member of sulfacetamide sodium anhydrous.

What are the applications of Application

Sulfacetamide sodium salt is a sulfonamide antibiotic

General Description

N-Sulfanilylacetamide monosodium salt (Sodium Sulamyd)is obtained as the monohydrate and is a white, odorless, bitter,crystalline powder that is very soluble (1:2.5) in water.Because the sodium salt is highly soluble at the physiologicalpH of 7.4, it is especially suited, as a solution, forrepeated topical applications in the local management ofophthalmic infections susceptible to sulfonamide therapy.

Biochem/physiol Actions

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.