(S,R,S)-AHPC-PEG3-Alkyne

Synonym(s):(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;Crosslinker–E3 Ligase ligand conjugate;Protein degrader building block for PROTAC research;Template for synthesis of targeted protein degrader;VH032 conjugate

CAS NO.：2374122-30-0
Empirical Formula: C32H44N4O7S
Molecular Weight: 628.79
MDL number: MFCD32173788
Update Date: 2026-01-13 11:26:16

What is (S,R,S)-AHPC-PEG3-Alkyne?

The Uses of (S,R,S)-AHPC-PEG3-Alkyne

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Properties of (S,R,S)-AHPC-PEG3-Alkyne

Boiling point:	881.7±65.0 °C(Predicted)
Density	1.224±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	14.07±0.40(Predicted)

Safety information for (S,R,S)-AHPC-PEG3-Alkyne

Computed Descriptors for (S,R,S)-AHPC-PEG3-Alkyne

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