Sphingosylphosphorylcholine

Chemical properties

Yellowish Waxy Solid

The Uses of Sphingosylphosphorylcholine

Neurotrophic effects of Sphingosylphosphorylcholine were studied in cerebellar granule neurons of mice and PC-12 cells.

The Uses of Sphingosylphosphorylcholine

Involved in cell regulation, and transmembrane signaling. A putative lipid second messenger, connected via Protein Kinase C to the phosphatidylinositol-derived second messengers for signal transduction.

The Uses of Sphingosylphosphorylcholine

Lyso SM (d18:1) has been used:

• to study its effect on the skeletal muscle ryanodine receptor (RyR1), in the presence and absence of calmodulin through single channel recordings in planar lipid bilayers
• as an inhibitor of Ca²⁺ sensor calmodulin (CaM)
• as a standard in circular dichroism (CD) spectroscopy to determine lipid selectivity of the lipid-peptide interactions

What are the applications of Application

Sphingosylphosphorylcholine, D-erythro is a sphingosine metabolite and activator of a variety of pathways

Definition

ChEBI: Sphingosine-1-phosphocholine is a phosphosphingolipid consisting of sphingosine having a phosphocholine moiety attached to its primary hydroxyl group. It is a phosphosphingolipid, a member of phosphocholines and an ammonium betaine. It is functionally related to a sphingosine. It is a conjugate base of a sphingosylphosphocholine acid and a sphingosine-1-phosphocholine(1+).

General Description

Lyso SM (d18:1), also known as sphingosylphosphorylcholine (SPC), is a bioactive lipid molecule. This lysophospholipid is present in normal blood plasma, ascites and various tissues.

Biochem/physiol Actions

Sphingosylphosphorylcholine (SPC) is a bioactive lipid that mediates intracellular and extracellular signaling. It mobilizes Ca2+ from intracellular stores via an IP3-independent pathway. It stimulates the production of CCL2 that may contribute to development of atherosclerosis. SPC is a ligand for endothelial differentiation gene receptor 3 (EDG3).