SPDP-PEG4-NHS ester

CAS NO.：1334177-95-5
Empirical Formula: C23H33N3O9S2
Molecular Weight: 559.65
MDL number: MFCD13185001
Update Date: 2025-04-18 09:52:54

What is SPDP-PEG4-NHS ester?

Description

SPDP-PEG4-NHS ester is a PEG linker containing an SPDP crosslinker and an NHS ester. The SPDP crosslinker is reactive toward amine and thiol groups and contains a cleavable disulfide bond. This crosslinker is also membrane permeable which allows for intracellular reactions to take place. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Properties of SPDP-PEG4-NHS ester

Density	1.34±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO, DCM, DMF
pka	15.01±0.46(Predicted)
form	solid or viscous liquid
color	White or Colorless to Almost white or Almost colorless

Safety information for SPDP-PEG4-NHS ester

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.