Sp-Cyclic AMPS (sodium salt)

Description

Several cyclic nucleotide phosphodiesterases (PDE2, -5, -6, -10, and -11) contain a tandem of GAF domains in their N-terminal regulatory region that are thought to mediate cAMP- or cGMP-induced stimulation of adenylyl and guanylyl cyclases. Sp-cyclic AMPS (Sp-cAMPS) is a derivative of cAMP that binds the PDE10 GAF domain (EC₅₀ = 40 μM). It has been used to study GAF-mediated stimulation of PDE10.

References

[1] dostmann w r, taylor s s, genieser h g, et al. probing the cyclic nucleotide binding sites of camp-dependent protein kinases i and ii with analogs of adenosine 3', 5'-cyclic phosphorothioates[j]. journal of biological chemistry, 1990, 265(18): 10484-10491.
[2] hanks s k, quinn a m, hunter t. the protein kinase family: conserved features and deduced phylogeny of the catalytic domains[j]. science, 1988, 241(4861): 42-52.
[3] spicuzza l, belvisi m g, birrell m a, et al. evidence that the anti‐spasmogenic effect of the β‐adrenoceptor agonist, isoprenaline, on guinea‐pig trachealis is not mediated by cyclic amp‐dependent protein kinase[j]. british journal of pharmacology, 2001, 133(8): 1201-1212.