Sodium trifluoromethanesulfinate

Chemical properties

White to light yellow solid

The Uses of Sodium trifluoromethanesulfinate

Efficient sulfinate salt for the trifluoromethylation of various aryls, aryl boronic acids, alkenes, and alkynes.

The Uses of Sodium trifluoromethanesulfinate

Sodium Triflinate (Sodium trifluoromethanesulfinate), is a sulfur-containing building block and Fluorination reagents, used in various organic synthesis. It can be used in a new and convenient method for the copper-catalyzed construction of functional sulfonamides in good yields and excellent chemoselectivity.

What are the applications of Application

Sodium trifluoromethanesulphinate is a halogenated compound used for proteomics research

Solubility in water

soluble in H2O, slightly soluble in MeOH, MeCN, and acetone.

Synthesis

At first, an aqueous solution was prepared by dissolving 37.5 g of sodium sulfite in 150 g of water. Then, a metal pressure-proof reactor was charged with this aqueous solution. After that, the atmosphere of the reactor was removed to obtain a reduced pressure. 10.7 g of trifluoromethanesulfonic fluoride was added to the reactor, stirring at 5° C. for 4 hr. The resulting reaction liquid was neutralized with sodium carbonate, followed by water removal. Then, methanol was added to the remaining solid matter to extract the target product. The resulting methanol solution was concentrated to dryness, thereby obtaining 9.7 g of sodium trifluoromethanesulfinate (yield: 88%).