Sodium periodate

Description

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. It may also be regarded as the sodium salt of periodic acid. Like many periodates it can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. Both salts are useful oxidising agents.

The Uses of Sodium periodate

Sodium Periodate is the sodium salt of periodic acid used to oxidize cellulose. Sodium Periodate oxidation is often used to selectively label RNA, saccharides and other compounds with vicinal diols.

The Uses of Sodium periodate

The SM (1.03 g, 3.58 mmol), NaIO4 (2.34 g, 10.9 mmol), OsO4 (2.5 wt% in t-BuOH, 1.0 mL), THF (12.4 mL), and H2O (2.4 mL) were combined at RT. The reaction mixture was stirred overnight in the dark, after which time it was diluted with H2O and DCM. The layers were separated using a hydrophobic frit. The org layer was dried (Na2SO4) and concentrated. The residue was purified by silica gel flash chromatography to provide the product as an amber oil. [786 mg, 76%]

What are the applications of Application

Sodium periodate is a strong oxidizing hypervalent iodine compound