Sodium iodide

Absorption

Iodide salts are readily absorbed in the gastrointestinal tract .

Toxicity

Acute oral LD50 is 4340 mg/kg in rat and 1000 mg/kg in mouse . Chronic iodide overdoses may result in iodism, which is commonly characterized by salivation, coryza, sneezing, conjunctivitis, headache, fever, laryngitis, bronchitis, stomatitis, parotitis and oedema of the glottis . Up to 10g of sodium iodide has been administered intravenously without any signs of toxicity .

The Uses of Sodium iodide

Sodium iodide was used as a component in the preparation of Mayer′s hematoxylin stain solution.
It may be used in the following processes:

• Precursor in the polymerization of butyl acrylate.
• Chaotropic agent in the extraction of DNA.
• Deprotecting agent in the removal of N-tert-butyloxycarbonyl group in amino acids.
• Water-soluble fluorescence quenching reagent.

What are the applications of Application

Sodium iodide is a useful reactant in the Finkelstein reaction

Indications

Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). When intravenously administered for total parental nutrition, sodium iodide prevents the depletion of endogenous stores of iodine and subsequent deficiency symptoms .

Background

Sodium iodide is a compound forming white, odourless deliquescent crystals. It is a water-soluble ionic compound with a crystal lattice. Sodium iodide is a source of iodine and can be administered as a supplement for total parenteral nutrition, but it is more commonly used in veterinary medicine. It is used as an iodine supplement and expectorant. Radiolabelled compound, Iodide I-131, is used as a diagnostic tool to evaluate thyroid function and morphology.