SMI-16a

CAS NO.：587852-28-6
Empirical Formula: C13H13NO3S
Molecular Weight: 263.31
MDL number: MFCD31382191
Update Date: 2026-04-24 14:58:09

What is SMI-16a?

Description

SMI-16a is a Pim-1 kinase inhibitor (IC₅₀ = 63 nM). It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 μM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G₁ phase in DU145 cells.

Properties of SMI-16a

Melting point:	186.3-188.4 °C
Density	1.303±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	Ethanol:3.0(Max Conc. mg/mL);11.39(Max Conc. mM)
form	A solid
pka	7.27±0.20(Predicted)
color	Light yellow to yellow

Safety information for SMI-16a

Computed Descriptors for SMI-16a

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