Slv320

CAS NO.：251945-92-3
Empirical Formula: C18H20N4O
Molecular Weight: 308.38
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-20 19:14:41

What is Slv320?

Description

Derenofylline is an adenosine A₁ receptor antagonist (K_i = 1 nM). It is selective for adenosine A₁ over A_2A, A_2B, and A₃ receptors (K_is = 398, 3,981, and 200 nM, respectively). It decreases adenosine A₁ receptor-mediated adenosine-induced bradycardia in rats (ED₅₀ = 0.49 mg/kg) but reduces A₂ receptor-mediated adenosine-induced hypotension by only 44.6% when administered at an intravenous dose of 5 mg/kg. It prevents increases in heart levels of collagen I and III in nephrectomized rats when administered at a dose of 10 mg/kg per day. Derenofylline also reduces relative plaque counts in a Zika virus plaque-forming assay in A549 cells (IC₅₀ = 58.6 nM) in an adenosine A₁ receptor-independent manner without inducing cytotoxicity when used at concentrations less than 10 μM.

The Uses of Slv320

SLV 320 is an A1 antagonist.

What are the applications of Application

SLV 320 is a selective Adenosine A1-R antagonist

Properties of Slv320

Boiling point:	532.3±60.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Soluble to 100 mM in DMSO and to 50 mM in ethanol
form	Powder
pka	15.15±0.40(Predicted)
color	White to off-white

Safety information for Slv320

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Slv320

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