SLMP53‐1

CAS NO.：1643469-17-3
Empirical Formula: C20H18N2O2
Molecular Weight: 318.37
Update Date: 2025-10-29 15:43:00

What is SLMP53‐1?

Biological Activity

SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels[1][2].

References

[1]. Gomes S, et al. SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel). 2019 Aug 10;11(8):1151.[2]. Ramos H, et al. SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. Int J Mol Sci. 2020 Jan 17;21(2):596.

Properties of SLMP53‐1

Boiling point:	561.5±50.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (785.25 mM; ultrasonic and warming and heat to 80°C)
form	Solid
pka	17.07±0.30(Predicted)
color	White to off-white

Safety information for SLMP53‐1

Computed Descriptors for SLMP53‐1

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