SKOV3 Cells GFP-HER2

Molecular Weight: 0
Update Date: 2026-01-13 11:19:51

What is SKOV3 Cells GFP-HER2?

The Uses of SKOV3 Cells GFP-HER2

SKOV3 Cells GFP-HER2 has been used for live-cell screening assays to find compounds that affect cell structure or signaling pathways.

General Description

SKOV3 GFP-HER2 are ovarian adenocarcinoma cells from a human 64 year old caucasion female having a ZFN modification creating a HER2-GFP transgene expressed from the endogenous HER2 gene locus.

This cell line was derived from ATCC Catalog No. HTB-77.

Biochem/physiol Actions

Human epidermal growth factor receptor 2 (HER2) signaling pathway promotes cell proliferation and survival in majority of breast cancers. Thus, overexpression of this protein leads to breast cancer. Heterodimeric complex of HER2 and phosphatidylinositide 3-kinase (PI3K) is the most potent stimulator of the phosphatidylinositol-3-kinase (PI3K)/Akt anti-apoptosis pathway. Upregulated expression of HER2 is associated with the development of ovarian, colorectal, pancreatic, endometrial and gastric cancers. Trastuzumab, an antibody, works by binding to a domain in the external domain of HER2. This domain is missing in p95, a truncated form of HER2, and hence these cancer cells show resistance to trastuzumab. HER2 protein can be used as a prognostic marker and as a therapeutic option for gynecologic cancers.

Properties of SKOV3 Cells GFP-HER2

storage temp.

-196°C

Safety information for SKOV3 Cells GFP-HER2

Computed Descriptors for SKOV3 Cells GFP-HER2

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