SKI-2852
- CAS NO.：1346554-47-9
- Empirical Formula: C27H34FN5O4S
- Molecular Weight: 543.65
- Update Date: 2026-04-24 14:58:24
What is SKI-2852?
Description
SKI2852 is a Highly Potent, Selective, and Orally Bioavailable Inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) potentially for treatment of diabetics. SKI2852 bioactivity data: hHSD1 IC50 = 2.9nM; mHSD1 IC50 = 1.6nM; HEK293 IC50 = 4/4 nM; Mous PK: F = 96%; CYP3A4 IC50 > 10 μM; CYP2C19 IC50 > 10 μM. SKI2852 demonstrated no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity. Repeated oral administration of SKI2852 significantly reduced blood glucose and HbA1c levels and improved the lipid profiles in ob/ob mice.
Properties of SKI-2852
| Density | 1.44±0.1 g/cm3(Predicted) |
| pka | 12.28±0.40(Predicted) |
Safety information for SKI-2852
Computed Descriptors for SKI-2852
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