SK&F 89976-A

CAS NO.：85375-85-5
Empirical Formula: C22H25NO2
Molecular Weight: 335.44
MDL number: MFCD01321071
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-05 15:21:26

What is SK&F 89976-A?

Description

SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo.

Definition

ChEBI: 1-(4,4-diphenylbut-3-enyl)-3-piperidinecarboxylic acid is a diarylmethane.

Properties of SK&F 89976-A

Boiling point:	531.4±50.0 °C(Predicted)
Density	1.121±0.06 g/cm3(Predicted)
pka	3.87±0.20(Predicted)

Safety information for SK&F 89976-A

Computed Descriptors for SK&F 89976-A

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