SHP099 (hydrochloride)

CAS NO.：2200214-93-1
Empirical Formula: C16H20Cl3N5
Molecular Weight: 388.72
MDL number: MFCD30343849
Update Date: 2026-07-16 07:06:08

What is SHP099 (hydrochloride)?

Description

SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1). Because it is an oncoprotein associated with multiple cancer-related diseases, as well as a potential immunomodulator, controlling SHP2 activity is of significant therapeutic interest.

Properties of SHP099 (hydrochloride)

solubility	DMSO:41.05(Max Conc. mg/mL);105.6(Max Conc. mM) Methanol:25.0(Max Conc. mg/mL);64.31(Max Conc. mM) Water:4.25(Max Conc. mg/mL);10.93(Max Conc. mM)
form	Solid
color	Yellow to orange

Safety information for SHP099 (hydrochloride)

Computed Descriptors for SHP099 (hydrochloride)

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