SHMT-IN-1

CAS NO.：1508286-18-7
Empirical Formula: C18H16Cl2N4O
Molecular Weight: 375.25
MDL number: MFCD34469611
Update Date: 2026-01-05 11:31:08

What is SHMT-IN-1?

Biological Activity

SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). SHMT-IN-1 has antitumor activity[1].

References

[1]. Witschel MC, et al. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. J Med Chem. 2015 Apr 9;58(7):3117-30.

Properties of SHMT-IN-1

Boiling point:	634.6±55.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (666.22 mM; Need ultrasonic)
pka	11.46±0.70(Predicted)
form	Solid
color	White to off-white

Safety information for SHMT-IN-1

Computed Descriptors for SHMT-IN-1

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