Shikalkin
- CAS NO.：54952-43-1
- Empirical Formula: C16H16O5
- Molecular Weight: 288.3
- MDL number: MFCD00016668
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-17 10:03:36
What is Shikalkin?
The Uses of Shikalkin
Shikonin has been used:
- to enhance the anti-tumor activity of gefitinib on tyrosine kinase receptor epidermal growth factor receptor (EGFR) in wild-type lung cancer cells
- as an inhibitor of renal aerobic glycosis and a potential
- as an anti-inflammatory agent to test its role to improve lipopolysaccharide (LPS)-induced cardiac dysfunction
- to stimulate bone marrow-derived macrophages (BMDMs) to test the effect of Interferon regulatory factor 1 on cell death
Definition
ChEBI: C.I. Natural Red 20 is a naphthoquinone.
General Description
Shikonin is a major phytochemical compound extracted from the roots of Lithospermum erythrorhizon. It is a natural anthraquinone derivative.
Biochem/physiol Actions
Shikonin is a potent anti-fungal agent against C. albicans biofilms. It displays anti-oxidant and chemotherapeutic properties on human glioma cells.
Properties of Shikalkin
| Melting point: | 144-145 °C |
| Boiling point: | 567.4±50.0 °C(Predicted) |
| Density | 1.373±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble1mg/mL |
| form | powder or solid |
| pka | 7.34±0.20(Predicted) |
| color | red to brown |
Safety information for Shikalkin
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Shikalkin
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