Semicarbazide

Description

Semicarbazide (SM) is a metabolite of the nitrofurane Nitrofurazone (5-nitro-2- furaldehyde-semicarbazone), used as indicator to detect the use of nitrofurazone in food-producing animals
due to their carcinogenic properties the use of nitrofurans is prohibited within the EU in animal breeding (Commission Regulation 37/2010) .
to harmonise the detection of semicarbazide a Minimum Required Performance Limit (MRPL) of 1 µg/kg is set within the EU (Commission Decision 2003/181).

What are the applications of Application

Semicarbazide is a useful TLC plate stain and precursor to antibacterial compounds

Definition

ChEBI: A monocarboxylic acid amide that is urea where one of the amino groups has been replaced with hydrazine.

Toxicology

Limited toxicological data are available for semicarbazide. It belongs, however, to a family of chemicals (hydrazines) which are known to cause cancer in animals. Semicarbazide is weakly genotoxic in some in vitro tests. The limited in vivo experimental data available are insufficient to assess whether the activity observed in vitro is also expressed in vivo. Semicarbazide appears to be only a weak carcinogen.