SELEXIPAG interMediate

CAS NO.：475086-75-0
Empirical Formula: C23H27N3O
Molecular Weight: 361.48
MDL number: MFCD28411750
EINECS: 813-799-3
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-04 14:23:20

What is SELEXIPAG interMediate?

The Uses of SELEXIPAG interMediate

4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-butanol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is an impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.

What are the applications of Application

Selexipag interMediate is a synthetic organic compound that is used as an intermediate in the synthesis of oxychloride. It is an oxychloride with a nucleophilic substitution reaction. The reaction proceeds selectively at the phosphorus atom and gives high yield. The reactivity of 4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butan-1-ol is enhanced by the use of n butanol, which also acts as a solvent for the reaction. The product can be purified by filtration or recrystallization from hexane with piperazine as a reagent.

Properties of SELEXIPAG interMediate

Melting point:	68 - 71°C
Boiling point:	514.4±50.0 °C(Predicted)
Density	1.112±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly)
form	Solid
pka	15.05±0.10(Predicted)
color	Pale Yellow to Light Yellow

Safety information for SELEXIPAG interMediate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.