SBC-115337

CAS NO.：423148-46-3
Empirical Formula: C29H19N3O4
Molecular Weight: 473.48
MDL number: MFCD02210564
Update Date: 2026-04-20 17:00:22

What is SBC-115337?

Biological Activity

SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2]. The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet[2].

References

[1]. Xu S, et al. Small molecules as inhibitors of PCSK9: Current status and future challenges. Eur J Med Chem. 2019;162:212-233. [2]. Lavecchia A, et al. Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy. Future Med Chem. 2019;11(5):423-441.

Properties of SBC-115337

Boiling point:	539.4±40.0 °C(Predicted)
Density	1.394±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	12.36±0.70(Predicted)
form	Solid
color	Light yellow to brown

Safety information for SBC-115337

Computed Descriptors for SBC-115337

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