SAR156497

CAS NO.：1256137-14-0
Empirical Formula: C27H24N4O4
Molecular Weight: 468.5
MDL number: MFCD28411357
Update Date: 2026-04-14 09:55:04

What is SAR156497?

Description

SAR156497 is an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy with IC50 = 0.5 nM (Aurora A); 1 nM (Aurora B / incenp); 3 nM (Aurora C / incenp) respectively SAR156497 combines high in vitro potency with satisfactory metabolic stability and limited CYP 3A4 and PDE3 inhibition. In vitro, SAR156497 displayed high antiproliferative activity on a large panel of tumor cell lines without correlation with any particular genetic signature or Aurora kinases expression. It induced significant modulation of Aurora A and Aurora B biomarkers (p-Aurora A and pHH3, respectively) and cell polyploidy, as expected from Aurora A/B inhibitors.

Properties of SAR156497

Boiling point:	718.6±70.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
pka	10.45±0.10(Predicted)

Safety information for SAR156497

Computed Descriptors for SAR156497

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