SAR-20347

Synonym(s):2-(2-Chloro-6-fluorophenyl)-5-(4-(morpholine-4-carbonyl)phenylamino)oxazole-4-carboxamide;2-(2-Chloro-6-fluorophenyl)-5-[[4-(4-morpholinylcarbonyl)phenyl]amino]-4-oxazolecarboxamide;SAR 20347;SAR20347

CAS NO.：1450881-55-6
Empirical Formula: C21H18ClFN4O4
Molecular Weight: 444.84
MDL number: MFCD28502117
Update Date: 2025-10-14 17:29:04

What is SAR-20347?

The Uses of SAR-20347

SAR-20347 is a small molecule inhibitor with specificity for JAK1 and tyrosine kinase 2 (TYK2).

Biochem/physiol Actions

SAR-20347 is an orally active, ATP-competitive, TYK2- and JAK1-selective tyrosine kinase inhibitor (IC50 = 13 nM/TYK2 & 59 nM/JAK1 vs. 0.88 μM/JAK2 & 1.44 μM/JAK3 with 10 μM ATP) that effectively inhibits cellular TYK2- (IL12-induced pSTAT4 IC50 = 107 nM/CD4+ cells, 126 nM/NK-92) and JAK1- (IL6-induced pSTAT3 IC50 = 345 nM/TF-1, 407 nM/CD14+ cells) mediated signaling with little affinity toward 72 other kinases. SAR-20347 suppresses IL22-induced serum amyloid A (by 44%; 50 mg/kg p.o. 30 min prior to 10 μg IL22 i.p.) and alleviates imiquimod-induced psoriasis-like dermatitis (30 min prior and 5 h post daily 62.5 mg 5% imiquimod cream) in mice in vivo.

Properties of SAR-20347

Boiling point:	698.3±65.0 °C(Predicted)
Density	1.445±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:94.5(Max Conc. mg/mL);212.43(Max Conc. mM)
form	A solid
pka	13.97±0.50(Predicted)
color	Light yellow to yellow