SALVINORIN A

Description

Salvinorin A (Item No. 11487) is an analytical reference material categorized as a diterpene. It is a hallucinogen derived from S. divinorum that has been used in the traditional spiritual practices of the Mazatec Indians and as a recreational drug. This product is intended for research and forensic applications.

Description

Salvinorin A, the most potent naturally occurring hallucinogen, is found in Salvia divinorum, a rare Mexican plant from the mint family. It was described and named in 1982 by A. Ortega and co-workers. At least 12 similar compounds have been discovered or synthesized, but none are appreciably psychoactive. Unlike most hallucinogens, salvinorin A is a terpenoid, not an alkaloid. In 2007, D. A. Evans and co-workers reported an asymmetric synthesis of salvinorin A.

The Uses of SALVINORIN A

Salvinorin A is a potent and selective kappa-opioid receptor agonist. Salvinorin A has been reported to be brain-penetrant and displays psychoactive properties; hallucinogen.

The Uses of SALVINORIN A

Salvinorin A is a hallucinogenic derived from the S. divinorum plant used in traditional spiritual practices of the Mazatec Indians and now gaining popularity as a recreational drug. Unlike other hallucinogens, which mediate their effects through serotonin 5-HT2A receptors, salvinorin A is a potent, selective κ-opioid receptor agonist (Ki = 2.4 nM; EC50 = 1.8 nM). This product is intended for forensic and research applications.In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

The Uses of SALVINORIN A

In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

Definition

ChEBI: A natural product found in Salvia divinorum.

Biological Activity

Potent naturally occuring non-nitrogenous κ -opioid selective agonist that displays high affinity at both native (K i = 4.3 nM) and cloned (K i = 16 nM) κ -opioid receptors. Also exhibits allosteric modulation of μ -opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties.

Biochem/physiol Actions

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.