Sacubitril Sodium

CAS NO.：149690-05-1
Empirical Formula: C24H28NNaO5
Molecular Weight: 433.47259
MDL number: MFCD32004488
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is Sacubitril Sodium ?

Description

Sacubitril Sodium is a potent orally active NEP (enkephalinase) inhibitor with an IC50 of 5 nM. Sacubitril Sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril Sodium is a component of the heart failure drug LCZ696. Sacubitril Sodium is used in heart failure, hypertension and COVID-19 studies.

The Uses of Sacubitril Sodium

Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Properties of Sacubitril Sodium

Melting point:	163-165°C
storage temp.	-20°C, Hygroscopic
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
Stability:	Hygroscopic

Safety information for Sacubitril Sodium

Computed Descriptors for Sacubitril Sodium

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