(S)-4-Hydroxy-2-pyrrolidinone
Synonym(s):(S)-β-Hydroxy-γ-butyrolactam
- CAS NO.：68108-18-9
- Empirical Formula: C4H7NO2
- Molecular Weight: 101.1
- MDL number: MFCD00273370
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:14:12
What is (S)-4-Hydroxy-2-pyrrolidinone?
Chemical properties
White crystal
The Uses of (S)-4-Hydroxy-2-pyrrolidinone
The (S)-enantiomer intermediate in the preparation of Oxiracetam
The Uses of (S)-4-Hydroxy-2-pyrrolidinone
(S)-(?)-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:
- Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
- Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.
General Description
4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.
Properties of (S)-4-Hydroxy-2-pyrrolidinone
| Melting point: | 156-159 °C (lit.) |
| Boiling point: | 363.6±35.0 °C(Predicted) |
| alpha | -41 º (c=% in ethanol) |
| Density | 1.292±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| Water Solubility | Slightly soluble in water |
| form | Solid |
| pka | 13.62±0.20(Predicted) |
| color | White to off-white |
| optical activity | [α]23/D 43°, c = 1 in ethanol |
| BRN | 1524192 |
| CAS DataBase Reference | 68108-18-9(CAS DataBase Reference) |
Safety information for (S)-4-Hydroxy-2-pyrrolidinone
| Signal word | Warning |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-4-Hydroxy-2-pyrrolidinone
| InChIKey | IOGISYQVOGVIEU-VKHMYHEASA-N |
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