(S)-1-N-Boc-2-methylpiperazine

CAS NO.：169447-70-5
Empirical Formula: C10H20N2O2
Molecular Weight: 200.28
MDL number: MFCD01862121
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:50:56

What is (S)-1-N-Boc-2-methylpiperazine?

The Uses of (S)-1-N-Boc-2-methylpiperazine

(S)-1-N-Boc-2-methylpiperazine is used in the preparation of pyrazolo[3,4-b]pyridine dual pharmacophores as PDE4-muscarinic antagonists.

Synthesis

A solution of (S)-2-methyl piperazine (2 g, 20 mmol) in THF (200 ml_) was mixed with nBuLi (25 ml, 1.6 M in hexanes, 40 mmol) at rt. The solution was stirred for 30 minutes before TBDMSCI (3.04 g, 20 mmol) was added. The mixture was stirred for 1 hour and then (Boc)2O (5.2 g, 24 mmol) was added to the solution. After 1 hour, the solution was diluted with H2O (50 ml). The organic layer was separated, washed with brine (50 mL), dried over Na2SO4, and concentrated EPO under vacuum. Finally, (S)-1-N-Boc-2-methylpiperazine was obtained after purification.

Properties of (S)-1-N-Boc-2-methylpiperazine

Melting point:	43.0 to 47.0 °C
Boiling point:	268.7±15.0 °C(Predicted)
Density	0.997±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	8.49±0.40(Predicted)
color	White to Almost white
InChI	InChI=1S/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1
CAS DataBase Reference	169447-70-5(CAS DataBase Reference)

Safety information for (S)-1-N-Boc-2-methylpiperazine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area.