RUVBL1/2 ATPase-IN-1

CAS NO.：423128-55-6
Empirical Formula: C28H28F3N5O
Molecular Weight: 507.55
Update Date: 2026-05-28 02:14:46

What is RUVBL1/2 ATPase-IN-1?

Biological Activity

RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases[1].

References

[1]. Zhang G, et al. Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem. 2022;62:116726.

Properties of RUVBL1/2 ATPase-IN-1

Density	1.29±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 10 mg/mL (19.70 mM; ultrasonic and warming and heat to 60°C)
pka	1.33±0.20(Predicted)
form	Solid
color	White to off-white

Safety information for RUVBL1/2 ATPase-IN-1

Computed Descriptors for RUVBL1/2 ATPase-IN-1

New Products

2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 4-(4-Αminophenyl)-3-Morpholinone 3-Morpholino-1-(4-(2-oxopiperidin-1-yl) phenyl)-5,6-dihyropyridin-2-(1H)-one 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one N-cyanoacetylurethane 1H-Indazole