Rubitecan
Synonym(s):9-nitrocamptothecin
- CAS NO.：91421-42-0
- Empirical Formula: C20H15N3O6
- Molecular Weight: 393.35
- MDL number: MFCD06656294
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:08
What is Rubitecan?
Description
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.
Chemical properties
Yellow Amorphous Powder
The Uses of Rubitecan
Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic
The Uses of Rubitecan
Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.
What are the applications of Application
Rubitecan is a DNA topoisomerase I inhibitor
Definition
ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Properties of Rubitecan
| Melting point: | 182-186°C |
| alpha | D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4) |
| Boiling point: | 816.3±65.0 °C(Predicted) |
| Density | 1.63 |
| Flash point: | 106℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Chloroform, Methanol |
| form | Solid |
| pka | 11.16±0.20(Predicted) |
| color | Yellow |
| Merck | 14,8288 |
| CAS DataBase Reference | 91421-42-0(CAS DataBase Reference) |
Safety information for Rubitecan
Computed Descriptors for Rubitecan
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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