Rubitecan
Synonym(s):9-nitrocamptothecin
- CAS NO.：91421-42-0
- Empirical Formula: C20H15N3O6
- Molecular Weight: 393.35
- MDL number: MFCD06656294
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:10
What is Rubitecan?
Description
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.
Chemical properties
Yellow Amorphous Powder
The Uses of Rubitecan
Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic
The Uses of Rubitecan
Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.
What are the applications of Application
Rubitecan is a DNA topoisomerase I inhibitor
Definition
ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Properties of Rubitecan
| Melting point: | 182-186°C |
| alpha | D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4) |
| Boiling point: | 816.3±65.0 °C(Predicted) |
| Density | 1.63 |
| Flash point: | 106℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Chloroform, Methanol |
| form | Solid |
| pka | 11.16±0.20(Predicted) |
| color | Yellow |
| Merck | 14,8288 |
| CAS DataBase Reference | 91421-42-0(CAS DataBase Reference) |
Safety information for Rubitecan
Computed Descriptors for Rubitecan
New Products
2-Ethoxyphenol Methyl 2-methoxy-5-sulfamoylbenzoate 3,6-Dichloropyridazine Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 3,6-Dichloro-4-Isopropylpyridazine 2-[(2-Ethoxyphenoxy)methyl]oxirane 4-Morpholinoaniline 2-Chloromethyl-6-methyl-pyridine 1-Indanone tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate 2-Pyridinecarboxaldehdye 6-Methyl-2-pyridinemethanol 4-Bromo-2-fluoro-N-methylbenzamide 3-Azetidinecarboxylic acid N-(2-(4-((4-Fluorobenzyl)carbamoyl)-5-hydroxy-6-methoxypyrimidin-2-yl)propan-2-yl)-5-methyl-1,3,4-oxadiazole-2-carboxamide (R)-4-Boc-morpholine-3-carboxylic acid (Required high chiral purity NLT:99.5%) Tetrahydro-3-(2-methyl-2- nitropropyl)-2H-pyran-2-one 3-Bromo-2-fluorobenzonitrile Desoximetasone Boron Triiodide Nicotinic acid RAPAMYCIN Pentachlorobenzonitrile BudesonideRelated products of tetrahydrofuran
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