RSM932A
Synonym(s):1,1′-[[[1,1′-Biphenyl]-4,4′-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium] bromide;1,1′-[[1,1′-Biphenyl]-4,4′-diylbis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium dibromide (9CI);RSM 932A;TCD-717
- CAS NO.：850807-63-5
- Empirical Formula: C46H38BrCl2N4+
- Molecular Weight: 797.64
- MDL number: MFCD29058562
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:14:16
What is RSM932A?
Description
RSM-932A is a selective inhibitor of choline kinase α (CHOKα; IC50s = 1 and >50 μM for CHOKα and β, respectively). It induces apoptosis via CHOP signaling and endoplasmic reticulum (ER) stress in MDA-MB-231, MCF-7, SW620, and H460 cancer cells, but it only induces cell cycle arrest and not apoptosis in NCM460 and MCF-10A normal epithelial cells. RSM-932A inhibits the growth of HT-29 colon cancer cells in vitro (IC50 = 1.15 μM) and in vivo in a mouse xenograft model (ED50 = 7.5 mg/kg).
Properties of RSM932A
| Melting point: | 255-257 °C |
| storage temp. | Store at -20°C |
| solubility | DMSO: 3 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml |
| form | A crystalline solid |
| color | White to yellow |
Safety information for RSM932A
Computed Descriptors for RSM932A
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