RSM932A

Synonym(s):1,1′-[[[1,1′-Biphenyl]-4,4′-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium] bromide;1,1′-[[1,1′-Biphenyl]-4,4′-diylbis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium dibromide (9CI);RSM 932A;TCD-717

CAS NO.：850807-63-5
Empirical Formula: C46H38BrCl2N4+
Molecular Weight: 797.64
MDL number: MFCD29058562
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-18 09:51:08

What is RSM932A?

Description

RSM-932A is a selective inhibitor of choline kinase α (CHOKα; IC₅₀s = 1 and >50 μM for CHOKα and β, respectively). It induces apoptosis via CHOP signaling and endoplasmic reticulum (ER) stress in MDA-MB-231, MCF-7, SW620, and H460 cancer cells, but it only induces cell cycle arrest and not apoptosis in NCM460 and MCF-10A normal epithelial cells. RSM-932A inhibits the growth of HT-29 colon cancer cells in vitro (IC₅₀ = 1.15 μM) and in vivo in a mouse xenograft model (ED₅₀ = 7.5 mg/kg).

Properties of RSM932A

Melting point:	255-257 °C
storage temp.	Store at -20°C
solubility	DMSO: 3 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml
form	A crystalline solid
color	White to yellow

Safety information for RSM932A

Computed Descriptors for RSM932A

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