RP 001 (hydrochloride)

CAS NO.：1781880-34-9
Empirical Formula: C24H25ClN4O4
Molecular Weight: 468.94
Update Date: 2026-07-16 07:06:08

What is RP 001 (hydrochloride)?

Description

RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P₁) agonist (EC₅₀ = 9 pM). It is competitive with W146 , a selective S1P₁ antagonist, and induces internalization and polyubiquitination of S1P₁ in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC₅₀ = 0.03 mg/kg). It reduces S1P₁-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1^eGFP/eGFP mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis.

The Uses of RP 001 (hydrochloride)

RP 001 Hydrochloride is a picomolar, short-acting S1P1 agonist.

Storage

Store at -20°C

Properties of RP 001 (hydrochloride)

storage temp.	Store at -20°C
solubility	DMSO: 100 mM
form	A solid

Safety information for RP 001 (hydrochloride)

Computed Descriptors for RP 001 (hydrochloride)

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