RORγt Inverse agonist 6

CAS NO.：1887161-80-9
Empirical Formula: C28H29ClN6O5
Molecular Weight: 565.02
MDL number: MFCD32263437
Update Date: 2026-05-27 23:45:07

What is RORγt Inverse agonist 6?

Biological Activity

RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo[1]. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model[1].RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng?h/mL at 1 mg/kg, po)[1].RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose[1].

References

[1]. Sato A, et al. Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists. ChemMedChem. 2019 Oct 28.

Properties of RORγt Inverse agonist 6

Density	1.46±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (88.49 mM; Need ultrasonic)
pka	11.82±0.70(Predicted)
form	Solid
color	White to off-white

Safety information for RORγt Inverse agonist 6

Computed Descriptors for RORγt Inverse agonist 6

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