ROR gamma-t-IN-1
- CAS NO.：1426802-50-7
- Empirical Formula: C23H18Cl2F3NO4S
- Molecular Weight: 532.36
- MDL number: MFCD28902182
- Update Date: 2025-12-29 14:06:09
What is ROR gamma-t-IN-1?
Description
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor''s putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 μM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.
Properties of ROR gamma-t-IN-1
| Boiling point: | 617.1±55.0 °C(Predicted) |
| Density | 1.434±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF:3.0(Max Conc. mg/mL);5.64(Max Conc. mM) DMSO:68.33(Max Conc. mg/mL);128.36(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.56(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);93.92(Max Conc. mM) |
| form | A crystalline solid |
| pka | 12.33±0.70(Predicted) |
| color | White to off-white |
Safety information for ROR gamma-t-IN-1
Computed Descriptors for ROR gamma-t-IN-1
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