ROR agonist-1
- CAS NO.：2361528-74-5
- Empirical Formula: C21H20F6N2O5S
- Molecular Weight: 526.45
- MDL number: MFCD32174299
- Update Date: 2026-01-04 19:55:51
What is ROR agonist-1?
Description
ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1]. pIC 50: 7.5 (human primary TH 17 cells)[1]
References
[1]. von Berg S, et al. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. ACS Med Chem Lett. 2019 May 29;10(6):972-977.
Properties of ROR agonist-1
| Boiling point: | 743.4±60.0 °C(Predicted) |
| Density | 1.455±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 9.24±0.15(Predicted) |
Safety information for ROR agonist-1
Computed Descriptors for ROR agonist-1
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