RO8994

CAS NO.：1309684-94-3
Empirical Formula: C31H31Cl2FN4O4
Molecular Weight: 613.51
MDL number: MFCD29472243
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-27 08:46:37

What is RO8994?

Description

RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC₅₀ = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC₅₀ value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively.

The Uses of RO8994

RO 8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy.

Properties of RO8994

Boiling point:	753.5±60.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM) DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM)
form	A crystalline solid
pka	12.00±0.70(Predicted)
color	White to off-white

Safety information for RO8994

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for RO8994

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