RO8994

CAS NO.：1309684-94-3
Empirical Formula: C31H31Cl2FN4O4
Molecular Weight: 613.51
MDL number: MFCD29472243
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 17:10:26

What is RO8994?

Description

RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC₅₀ = 5 nM). It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC₅₀ value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively.

The Uses of RO8994

RO 8994 is a potent and selective spiroindolinone MDM2 inhibitor, and potential useful for cancer therapy.

Properties of RO8994

Boiling point:	753.5±60.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF:12.5(Max Conc. mg/mL);20.4(Max Conc. mM) DMSO:14.0(Max Conc. mg/mL);22.8(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);8.1(Max Conc. mM)
form	A crystalline solid
pka	12.00±0.70(Predicted)
color	White to off-white

Safety information for RO8994

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for RO8994

New Products

Dexamethasone Sodium Phosphate 2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 8-Bromo-3-methyl xanthine Maleic hydrazide m-Tolualdehyde p-Anisaldehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid 2-Fluoro-6-iodobenzoic acid 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate 1-Boc-4-cyanopiperidine 3-Pyridineacrylic acid Abiraterone Ethyl Ether Vardenafil Bis-sulphonamide(Dimer) 1-nitro-3,5-dimethyl adamantine (NMEM) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5