Ro 67-7476

CAS NO.：298690-60-5
Empirical Formula: C17H18FNO2S
Molecular Weight: 319.39
MDL number: MFCD20270617
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-29 15:43:00

What is Ro 67-7476?

Description

Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC₅₀ = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC₅₀ = 163.3 nM).

The Uses of Ro 67-7476

Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator.

Storage

Store at RT

Properties of Ro 67-7476

Boiling point:	452.9±55.0 °C(Predicted)
Density	1.268±0.06 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM)
form	Powder
pka	-5.53±0.40(Predicted)
color	White to yellow

Safety information for Ro 67-7476

Computed Descriptors for Ro 67-7476

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