RO 65-6570 HYDROCHLORIDE

Synonym(s):(RS)-8-(1,2-Dihydro-1-acenaphthylenyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one Hydrochloride;(RS)-8-Acenaphthen-1-yl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride;Ro65-6570 Hydrochloride

CAS NO.：228246-34-2
Empirical Formula: C25H26ClN3O
Molecular Weight: 419.95
MDL number: MFCD31697736
Update Date: 2026-01-13 11:22:52

What is RO 65-6570 HYDROCHLORIDE?

Biochem/physiol Actions

Ro 65-6570 is a nonpeptidic, high-affinity (Ki = 0.52 against 0.1 nM OFQ for binding human ORL1) nociceptin/orphanin FQ (N/OFQ) receptor ORL-1 (KOR-3, NOP) agonist (EC50 = 40 nM by GTPγS binding assay; IC50 = 0.28 nM against 1 μM forskolin-stimulated cellular cAMP accumulation) with good selectivity over opioid receptors μ, k, δ (Ki = 5.9, 26, 250 nM against 1.5 nM naloxone, 3 nM naloxone, 0.3 nM [Ile5,6]-deltorphin II for binding respective receptors), dopamine and serotonin receptors (Ki = 520 nM/D2, 1210 nM/D3,350 nM/D4.4; Ki ≥1 μM for 5HT 1Dα, 2A, 2C, 6, 7). Ro 65-6570 elicits ORL1-dependent anxiolytic-like effects in rats in vivo (0.32-3.2 mg/kg i.p.; elevated plus maze) without affecting spontaneous locomotion. Unlike OFQ, Ro 65-6570 does not affect cocaine-induced conditioned place preference (CPP) in rats.

Properties of RO 65-6570 HYDROCHLORIDE

storage temp.	2-8°C
form	powder
color	white to beige

Safety information for RO 65-6570 HYDROCHLORIDE

Computed Descriptors for RO 65-6570 HYDROCHLORIDE

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