RO 5126946
- CAS NO.：1137233-79-4
- Empirical Formula: C19H21ClN2O4S
- Molecular Weight: 408.9
- Update Date: 2026-04-21 10:31:43
What is RO 5126946?
Description
RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of α7nAChRs from desensitization. In addition, RO5126946's effects were absent when nicotine-evoked currents were completely blocked by coapplication of the α7nAChR-selective antagonist methyl-lycaconitine.
Properties of RO 5126946
| Density | 1.40±0.1 g/cm3(Predicted) |
| pka | 10.19±0.10(Predicted) |
Safety information for RO 5126946
Computed Descriptors for RO 5126946
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