RO-31-8220

Synonym(s):3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, Bisindolylmaleimide IX, Methanesulfonate;Ro-31-8220 - CAS 138489-18-6 - Calbiochem

CAS NO.：138489-18-6
Empirical Formula: C25H23N5O2S
Molecular Weight: 457.55
MDL number: MFCD03788207
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is RO-31-8220?

The Uses of RO-31-8220

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

What are the applications of Application

Ro 31-8220 is a cell-permeable PKC inhibitor that has been shown to be selective for PKC over CaM kinase II and PKA

What are the applications of Application

Ro-31-8220 in solution is a serotonin 1A-receptor agonist used experimentally to test the effects of serotonin

General Description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

Storage

+4°C

Properties of RO-31-8220

storage temp.	2-8°C
solubility	DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM) DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM) DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM) Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)
form	Red solid
color	Red