RO-31-8220
Synonym(s):3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, Bisindolylmaleimide IX, Methanesulfonate;Ro-31-8220 - CAS 138489-18-6 - Calbiochem
- CAS NO.：138489-18-6
- Empirical Formula: C25H23N5O2S
- Molecular Weight: 457.55
- MDL number: MFCD03788207
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-02-02 18:10:39
What is RO-31-8220?
The Uses of RO-31-8220
Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.
What are the applications of Application
Ro 31-8220 is a cell-permeable PKC inhibitor that has been shown to be selective for PKC over CaM kinase II and PKA
What are the applications of Application
Ro-31-8220 in solution is a serotonin 1A-receptor agonist used experimentally to test the effects of serotonin
General Description
Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.
Biochem/physiol Actions
Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.
Storage
+4°C
Properties of RO-31-8220
| storage temp. | 2-8°C |
| solubility | DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM) DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM) DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM) Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM) |
| form | Red solid |
| color | Red |
Safety information for RO-31-8220
Computed Descriptors for RO-31-8220
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