Ro 25-6981 (Maleate)
- CAS NO.：1312991-76-6
- Empirical Formula: C26H33NO6
- Molecular Weight: 455.55
- MDL number: MFCD06798375
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:04:25
What is Ro 25-6981 (Maleate)?
The Uses of Ro 25-6981 (Maleate)
Ro 25-6981 maleate is a potent NMDA receptor antagonist.
What are the applications of Application
Ro 25-6981 maleate is a potent NMDA receptor antagonist
Definition
ChEBI: Ro 25-6981 maleate is the maleic acid salt of Ro 25-6981. It is a potent and selective antagonist of GluN2B-containing NMDA receptors. It has a role as an anticonvulsant, an antidepressant, a neuroprotective agent and a NMDA receptor antagonist. It contains a Ro 25-6981(1+).
Biochem/physiol Actions
Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC50 values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models.
Storage
Room temperature (desiccate)
Properties of Ro 25-6981 (Maleate)
| storage temp. | 2-8°C |
| solubility | H2O: soluble2mg/mL (clear solution, warmed) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +15 to +22°, c = 1 in methanol |
Safety information for Ro 25-6981 (Maleate)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Ro 25-6981 (Maleate)
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