RNA Polymerase III Inhibitor

Description

ML60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from?S. Cerevisiae?as well as from human cells, IC50=32?mM and 27?mM respectively.1?? Combined treatment with ML-60218 and an HDAC inhibitor caused augmented suppression of colony formation, induction of cell cycle arrest and apoptotic cell death in human pancreatic adenocarcinoma cells.2

What are the applications of Application

RNA Polymerase III Inhibitor is a cell-permeable indazolo-sulfonamide compound displaying inhibitory activity against RNA Polymerase III.

General Description

A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC₅₀ = 27 and 32 μM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).

Biochem/physiol Actions

Product does not compete with ATP.

References

1) Wu?et al.?(2003),?Novel small-molecule inhibitors of RNA polymerase III; Eukaryot. Cell,?2?256 2) Yee?et al.?(2012),?Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer; Biol. Open,?1(4)?295