Rimeporide

Synonym(s):EMD87580;N-[2-methyl-4,5-bis(methylsulfonyl)-benzoyl]-guanidine

CAS NO.：187870-78-6
Empirical Formula: C11H15N3O5S2
Molecular Weight: 333.38
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-22 18:57:36

What is Rimeporide?

The Uses of Rimeporide

EMD-87580 has been used as a selective and potent sodium-hydrogen antiporter 1 (NHE-1) inhibitor in cardiac ventricular myocytes to test its effect on the hypertrophic response.

Biochem/physiol Actions

EMD-87580 is a selective inhibitor of the Na+/H+ exchanger subtype 1 (NHE-1), also known as the Na+/H+ antiporter. EMD-87580 has shown cardioprotective effects, and has been investigated as a possible treatment for Duchenne′s muscular dystrophy.

Properties of Rimeporide

Density	1.55±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO : 20 mg/mL (59.99 mM)
form	powder
pka	10.50±0.46(Predicted)
color	white to beige

Safety information for Rimeporide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Rimeporide

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