Rho Kinase Inhibitor V

Synonym(s):N-(4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide;Rho Kinase Inhibitor V - CAS 1072906-02-5 - Calbiochem

CAS NO.：1072906-02-5
Empirical Formula: C18H15N3O3
Molecular Weight: 321.33
MDL number: MFCD28138106
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:59:07

What is Rho Kinase Inhibitor V?

What are the applications of Application

Rho Kinase Inhibitor V is a cell-permeable and potent, ATP-binding pocket-targeting inhibitor of ROCK-II

General Description

A cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of ROCK-II (IC₅₀ = 1.5 nM) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells (IC₅₀ = 72 nM). It afftects the activities of PKA, MRCK, Akt1 (IC₅₀ = 0.186, 1.19, and 1.41 μM, respectively) and CYP-450 enzymes (% inhibition of 2C9/2D6/3A4/1A2 at 10 μM = 87/40/1/20, respectively) only at much higher concentrations.

Properties of Rho Kinase Inhibitor V

Boiling point:	638.4±55.0 °C(Predicted)
Density	1.374±0.06 g/cm3(Predicted)
storage temp.	+2C to +8C
form	Light beige solid
pka	12.53±0.70(Predicted)

Safety information for Rho Kinase Inhibitor V

Computed Descriptors for Rho Kinase Inhibitor V

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