REVERSIN 121

Synonym(s):Boc-Asp(Obzl)-Lys(Z)-OtBu

CAS NO.：174630-04-7
Empirical Formula: C34H47N3O9
Molecular Weight: 641.75
MDL number: MFCD03788012
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:59:17

What is REVERSIN 121?

Description

Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a K_d value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.

The Uses of REVERSIN 121

Reversin 121 has been used to determine the activity of P-glycoprotein in human retinal pigment epithelium.

What are the applications of Application

Reversin 121 is an inhibitor of P-glycoprotein (MDR1)

General Description

Reversin 121 is an analog of reversin and a dipeptide derivative.

Biochem/physiol Actions

Peptide chemosensitizer, inhibitor of P-glycoprotein.

Properties of REVERSIN 121

Boiling point:	786.8±60.0 °C(Predicted)
Density	1.163±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMSO or ethanol: soluble
form	powder
pka	10.75±0.46(Predicted)
color	white

Safety information for REVERSIN 121

Computed Descriptors for REVERSIN 121

New Products

Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2-Bromo-5-hydroxybenzoic acid. 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile 5-Amino-2-Hydroxypyridine 2-Amino-5-Iodopyridine 2-BROMOACETYL BROMIDE-D2 METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 6-Chloro-pyrimidine-2,4-diamine 3-Oxide 1-Acetyl-4-(4-hydroxyphenyl)piperazine 1-(3-Chlorophenyl)piperazine hydrochloride