RET Kinase inhibitor 1

CAS NO.：1627856-64-7
Empirical Formula: C22H21F4N3O4
Molecular Weight: 467.41
MDL number: MFCD30747847
Update Date: 2025-10-29 15:43:00

What is RET Kinase inhibitor 1?

Description

GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC₅₀ = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC₅₀ = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.

Properties of RET Kinase inhibitor 1

Boiling point:	670.1±55.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM) Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM)
form	A crystalline solid
pka	10.30±0.10(Predicted)
color	White to off-white

Safety information for RET Kinase inhibitor 1

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.