RC574

CAS NO.：2584411-87-8
Empirical Formula: C18H24OSSe
Molecular Weight: 367.41
Update Date: 2025-04-17 18:22:24

What is RC574?

Biological Activity

RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1 It inhibits glutamate-induced cell death in HT22 cells (IC50 = 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells when used at concentrations ranging from 62.5 to 1,000 nM.

References

1.Bueno, D.C., Canto, R.F.S., de Souza, V., et al.New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cellsMol. Neurobiol.57(8)3273-3290(2020)

Properties of RC574

Boiling point:	408.9±45.0 °C(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 20 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
form	A crystalline solid
pka	11.88±0.70(Predicted)

Safety information for RC574

Computed Descriptors for RC574

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