rac-5,7-Dimethyltocol

Description

(±)-5,7-Dimethyltocol is a form of tocopherol.¹ It has similar antioxidant activity to α-tocol, but lower activity than γ-tocol, in antioxidant assays using menhaden oil or squalene as substrates. It also increases microviscosity of rat liver liposomes containing phosphatidylcholine (PC) by 70.6% when used at a molar ratio of 0.2 to PC.² (±)-Dimethyltocol has been used as an internal standard for the quantification of 5,7-tocol, α- and γ-tocopherol, and α- and γ-tocopheryl quinone by HPLC.³

References

1. Olcott, H.S., and Van der Veen, J. Comparison of antioxidant activities of tocol and its methyl derivatives Lipids 3(4),331-334(1968).
2. Urano, S., Inomori, Y., Sugawara, T., et al. Vitamin E: Inhibition of retinol-induced hemolysis and membrane-stabilizing behavior J. Biol. Chem. 267(26),18365-18370(1992).
3. Gao, R., Stone, W.L., Huang, T., et al. The uptake of tocopherols by RAW 264.7 macrophages Nutr. J. 1:2,(2002).